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Bioinformatics means combining the fields of statistics and computer science and applying them to the field of molecular biology form drug desinging ,analysis and other studies.

The term bioinformatics was given in 1978 by Paulien Hogeweg and Ben Hesper.Bioinformatics now entails the creation and advancement of databases, algorithms, computational and statistical techniques and theory to solve formal and practical problems arising from the management and analysis of biological data.

Over the past few decades rapid developments in genomic and other molecular research technologies and developments in information technologies have combined to produce a tremendous ount of information related to molecular biology. It is the name given to these mathematical and computing approaches used to glean understanding of biological processes.Common activities in bioinformatics include mapping and analyzing DNA and protein sequences, aligning different DNA and protein sequences to compare them and creating and viewing 3-D models of protein structures.

The primary goal of bioinformatics is to increase the understanding of biological processes. What sets it apart from other approaches, however, is its focus on developing and applying computationally intensive techniques (e.g., pattern recognition, data mining, machine learning algorithms, and visualization) to achieve this goal. Major research efforts in the field include sequence alignment, gene finding, genome assembly, drug design, drug discovery, protein structure alignment, protein structure prediction, prediction of gene expression and proteinâ?"protein interactions, genome-wide association studies and the modeling of evolution.

There are two fundamental ways of modelling a Biological system (e.g. living cell) both coming under Bioinformatic approaches
Static

Sequences Proteins, Nucleic acids and Peptides
Structures Proteins, Nucleic acids, Ligands (including metabolites and drugs) and Peptides
Interaction data among the above entities including microarray data and Networks of proteins, metabolites


Dynamic

Systems Biology comes under this category including reaction fluxes and variable concentrations of metabolites
Multi-Agent Based modelling approaches capturing cellular events such as signalling, transcription and reaction dynamics

A broad sub-category under bioinformatics is structural bioinformatics.

An Introduction to Bioinformatics
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What is Bioinformatics?
Bioinformatics is the application of computer technology to the management of biological information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied to gene-based drug ...

Human Genome Project
Begun formally in 1990, the U.S. Human Genome Project was a 13-year effort coordinated by the U.S. Department of Energy and the National Institutes of Health. The project originally was planned to last 15 years, but rapid ...

In-silico Drug Designing
In silico methods can help in identifying drug targets via bioinformatics tools. They can also be used to analyze the target structures for possible binding/ active sites, generate candidate molecules, check for their drug likeness ...

Careers in Bioinformatics
Bioinformatics or computational biology relates to the use of information technology in the field of molecular biology. It involves the application of computer technology for analysis and management of biological data. The computers are used to collect ...

Protein Structure Prediction
Protein structure prediction is the prediction of the three-dimensional structure of a protein from its amino acid sequence — that is, the prediction of its secondary, tertiary, and quaternary structure from its primary structure ...

Homology Modelling
Homology modeling, also known as comparative modeling of protein refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related ...

Application of Bioinformatics
Bioinformatics is the use of IT in biotechnology for the data storage, data warehousing and analyzing the DNA sequences. In Bioinfomatics knowledge of many branches are required like biology, mathematics, computer science, laws of physics ...

Bioinformatics in Proteomics
As with other subsets of biology, an increased ability to generate large amounts of data from the use of high throughput methods has led to an increased reliance on computers for data acquisition, storage, and analysis. The internet has ...

Bioinformatics in Genomics
Genomic technologies are generating an extraordinary amount of information, unprecedented in the history of Biology. Thus, a new scientific discipline, Bioinformatics, at the intersection between Biology and Computation, has ...

Bioinformatics in Medicine
Bioinformatics has become emerging field and has been used in various areas of research. The principal goal of bioinformatics is to enhance the understanding of biological processes. Bioinformatics implicates the establishment ...

Research in Bioinformatics
The European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI), which hosts the world’s largest public collection of molecular biology databases, is using the pan-European GÉANT research network and JANET ...

Structural Bioinformatics
Structural bioinformatics is the branch of bioinformatics which is related to the analysis and prediction of the three-dimensional structure of biological macromolecules such as proteins, RNA, and DNA. It deals with generalizations about ...

Protein Data Bank
The Protein Data Bank (PDB) is a repository for the 3-D structural data of large biological molecules, such as proteins and nucleic acids. (See also crystallographic database). The data, typically obtained by X-ray crystallography or NMR ...

NCBI
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988 ...

The Future of Bioinformatics
We are currently witnessing a technological revolution. With the increase of sequencing projects, bioinformatics continues to make considerable progress in biology by providing scientists with access to the genomic information ...

Bioinformatics Web Sites
General biocomputing services
* ReNaBi (France)
* GenomeNet WWW Server (Kyoto, Japan)
* Center for Information Biology (Mishima, Japan)
...

Online Bioinformatics Tools
Analysis of nucleotide and protein sequence data was initially restricted to those with access to complicated mainframe or expensive desktop computer programs (for example PC/GENE, Lasergene, MacVector, Accelrys etc.) ...